对于消费者

适用于西司他丁/亚胺培南：溶液粉

需要立即就医的副作用

西司他丁/亚胺培南及其所需的作用可能会引起一些不良作用。尽管并非所有这些副作用都可能发生，但如果确实发生了，则可能需要医疗护理。

服用西司他丁/亚胺培南时，如果有下列任何副作用，请立即咨询医生：

比较普遍;普遍上

• 混乱
• 抽搐（癫痫发作）
• 头晕
• 注射部位疼痛
• 皮疹，荨麻疹，瘙痒，发烧或喘息
• 震颤

不常见

• 头晕
• 出汗增加
• 恶心或呕吐
• 异常疲倦或虚弱

罕见

• 发热
• 严重的腹部或胃痉挛和疼痛
• 水样和严重的腹泻，也可能是流血的（这些副作用也可能在您停止服用此药后数周内发生）

不需要立即就医的副作用

西司他丁/亚胺培南可能会产生某些副作用，通常不需要医治。随着身体对药物的适应，这些副作用可能会在治疗期间消失。另外，您的医疗保健专业人员可能会告诉您一些预防或减少这些副作用的方法。

请咨询您的医疗保健专业人员，是否持续存在以下不良反应或令人讨厌，或者是否对这些副作用有任何疑问：

比较普遍;普遍上

• 腹泻
• 恶心和呕吐

对于医疗保健专业人员

适用于西司他丁/亚胺培南：注射剂，肌肉注射剂

本地

常见（1％至10％）：注射部位的静脉炎/血栓性静脉炎

罕见（0.1％至1％）：注射部位疼痛，注射部位红斑，静脉硬结，局部疼痛和注射部位硬结

未报告频率：灌注静脉感染，注射部位刺激，注射部位反应^[参考]

胃肠道

与粒细胞减少症患者相比，粒细胞减少症患者更容易出现与药物相关的恶心和/或呕吐。 ^[参考]

常见（1％至10％）：恶心，呕吐，腹泻

罕见（0.01％至0.1％）：伪膜性结肠炎

非常罕见（少于0.01％）：出血性结肠炎，胃肠炎，腹痛，舌炎，舌头乳头肥大，烧心，流涎增加

未报告频率：艰难梭菌相关性腹泻，口腔念珠菌病，便秘

上市后报告：牙齿和/或舌头的染色^[参考]

皮肤科

常见（1％至10％）：皮疹（如发烟性皮疹）

罕见（0.1％至1％）：瘙痒，荨麻疹

稀有（0.01％至0.1％）：多形性红斑，血管性水肿/血管神经性水肿，剥脱性皮炎

非常罕见（少于0.01％）：多汗症，皮肤纹理变化，念珠菌病

上市后报道：史蒂文斯-约翰逊综合征，中毒性表皮坏死

β-内酰胺类：

-未报告频率：严重的皮肤不良反应（包括史蒂文斯-约翰逊综合征，中毒性表皮坏死溶解，嗜酸性粒细胞增多和全身症状的药物反应[DRESS]，急性全身性皮疹性脓疱病） ^[Ref]

血液学

常见（1％至10％）：嗜酸性粒细胞增多

罕见（0.1％至1％）：血小板增多症，库姆斯试验阳性，凝血酶原时间延长，血红蛋白减少

未报告频率：嗜酸性粒细胞增加，白细胞增加，血小板增加，血红蛋白和血细胞比容减少，单核细胞增加，凝血酶原时间异常，淋巴细胞增加，嗜碱性粒细胞增多，嗜中性粒细胞减少，血小板计数增加/减少，血细胞比容增加/减少，贫血

上市后报告：全血细胞减少症，骨髓抑制，中性粒细胞减少症，血小板减少症，白细胞减少症，溶血性贫血，粒细胞缺乏症^[参考]

肝的

常见（1％至10％）：血清转氨酶升高

罕见（0.1％至1％）：胆红素升高

未报告的频率：ALT升高，AST升高，胆红素升高/降低

上市后报告：肝炎（包括暴发性肝炎），黄疸，肝衰竭^[参考]

其他

常见（1％至10％）：碱性磷酸酶增加

罕见（0.1％至1％）：发烧

非常罕见（小于0.01％）：潮红，乏力/虚弱

未报告频率：LDH增加，血清钠减少，钾增加，氯化物增加，面部浮肿，疼痛，重度感染

上市后报告：药物热^[参考]

神经系统

罕见（0.1％至1％）：癫痫发作，肌阵挛性活动，头晕，嗜睡

罕见（0.01％至0.1％）：脑病，感觉异常，震颤，听力下降

非常罕见（少于0.01％）：重症肌无力，头痛，眩晕，耳鸣加重

未报告频率：肌阵挛

上市后报告：震颤，运动障碍，味觉变态^[参考]

心血管的

罕见（0.1％至1％）：低血压

非常罕见（小于0.01％）：心pit，心动过速，发^[参考]

精神科

罕见（0.1％至1％）：混乱

上市后报告：精神障碍（包括幻觉），躁动

肾的

罕见（0.1％至1％）：BUN增加，肌酐增加

稀有（0.01％至0.1％）：少尿/无尿

上市后报告：急性肾衰竭^[参考]

泌尿生殖

稀有（0.01％至0.1％）：多尿

非常罕见（少于0.01％）：外阴瘙痒症

没有报告的频率：尿蛋白的存在，尿红细胞的存在，尿白细胞的存在，尿管的存在，尿胆红素的存在，尿液尿胆原原的存在，尿蛋白的增加，尿细菌的存在

上市后报告：尿液变色^[参考]

过敏症

稀有（0.01％至0.1％）：过敏反应

β-内酰胺类：

-频率未报告：超敏（过敏）反应^[参考]

呼吸道

非常罕见（少于0.01％）：胸部不适，呼吸困难，换气过度，咽痛^[参考]

肌肉骨骼

非常罕见（少于0.01％）：多关节痛，胸椎痛^[参考]

某些副作用可能没有报道。您可以将其报告给FDA。

成人细菌血症的常用剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌种类而怀疑/证实感染：每6小时静脉输注1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌类（包括脆弱类杆菌）易感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H菌，克雷伯菌属，粘质沙雷氏菌等易感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而引起的尿路感染（复杂和不复杂）

成人心内膜炎的常用剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌种类而怀疑/证实感染：每6小时静脉输注1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌类（包括脆弱类杆菌）易感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H，克雷伯菌，沙雷氏菌的敏感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而引起的尿路感染（复杂和不复杂）

成年人腹腔感染的常用剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌种类而怀疑/证实感染：每6小时静脉输注1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌类（包括脆弱类杆菌）易感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H，克雷伯菌，沙雷氏菌的敏感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而引起的尿路感染（复杂和不复杂）

成人关节感染的常用剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌种类而怀疑/证实感染：每6小时静脉输注1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌类（包括脆弱类杆菌）易感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H，克雷伯菌，沙雷氏菌的敏感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而引起的尿路感染（复杂和不复杂）

骨髓炎通常的成人剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌种类而怀疑/证实感染：每6小时静脉输注1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌类（包括脆弱类杆菌）易感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H，克雷伯菌，沙雷氏菌的敏感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而引起的尿路感染（复杂和不复杂）

成年人肺炎的常用剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌种类而怀疑/证实感染：每6小时静脉输注1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌类（包括脆弱类杆菌）易感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H，克雷伯菌，沙雷氏菌的敏感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而引起的尿路感染（复杂和不复杂）

肾盂肾炎通常的成人剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌物种而怀疑/证实感染：每6小时静脉注射1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌类（包括脆弱类杆菌）易感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H，克雷伯菌，沙雷氏菌的敏感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而导致的尿路感染（复杂和不复杂）

通常用于败血症的成人剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌物种而怀疑/证实感染：每6小时静脉注射1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌类（包括脆弱类杆菌）易感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H，克雷伯菌，沙雷氏菌的敏感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而引起的尿路感染（复杂和不复杂）

成人细菌感染的常用剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌物种而怀疑/证实感染：每6小时静脉注射1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌类（包括脆弱类杆菌）易感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H，克雷伯菌，沙雷氏菌的敏感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而引起的尿路感染（复杂和不复杂）

成年人尿路感染的常用剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌种类而怀疑/证实感染：每6小时静脉输注1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌类（包括脆弱类杆菌）易感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H，克雷伯菌，沙雷氏菌的敏感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而引起的尿路感染（复杂和不复杂）

成年人支气管炎的常用剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌种类而怀疑/证实感染：每6小时静脉输注1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌类（包括脆弱类杆菌）易感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H，克雷伯菌，沙雷氏菌的敏感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而引起的尿路感染（复杂和不复杂）

盆腔感染的常规成人剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌种类而怀疑/证实感染：每6小时静脉输注1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌类（包括脆弱类杆菌）易感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H，克雷伯菌，沙雷氏菌的敏感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而引起的尿路感染（复杂和不复杂）

子宫内膜炎的成人剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌物种而怀疑/证实感染：每6小时静脉注射1 g（亚胺培南成分）

用途：用于治疗：
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠埃希菌，克雷伯菌，铜绿假单胞菌，沙雷氏菌，拟杆菌等（包括脆弱拟杆菌）的敏感菌株而导致的细菌败血症
-粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），表皮葡萄球菌，肠杆菌，铜绿假单胞菌的易感菌株引起的骨和关节感染
-心内膜炎归因于金黄色葡萄球菌易感菌株（产生青霉素酶的菌株）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，无乳链球菌（B链球菌），肠杆菌属，大肠杆菌，阴道加德纳菌，克雷伯菌，变形杆菌，双歧杆菌属，肽球菌的易感菌株而引起的妇科感染菌属，肽链球菌属，丙酸杆菌属，拟杆菌属（包括脆弱类杆菌）
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的菌株），肠杆菌，柠檬杆菌，肠杆菌，大肠杆菌，克雷伯菌，摩根氏菌，变形杆菌，铜绿假单胞菌，双歧杆菌，梭菌，真细菌属，Peptococcus属，Peptostreptococcus属，Propionibacterium属，Bacteroides属（包括脆弱的B杆菌），Fusobacterium属
-由于金黄色葡萄球菌（产生青霉素酶的分离株），不动杆菌属，肠杆菌属，大肠杆菌，流感嗜血杆菌，副流感H，克雷伯菌，沙雷氏菌的敏感菌株而引起的下呼吸道感染
-由于粪肠球菌，金黄色葡萄球菌（产生青霉素酶的分离株），肠杆菌属，大肠杆菌，克雷伯菌，摩根氏菌，寻常变形杆菌，普罗特里斯氏菌，普罗维登斯氏菌，绿脓杆菌等易感菌株而引起的尿路感染（复杂和不复杂）

成年人皮肤或软组织感染的常用剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

如果由于中等敏感性细菌物种而怀疑/证实感染：每6小时静脉注射1 g（亚胺培南成分）

用途：用于治疗因粪便大肠杆菌，金黄色葡萄球菌（产生青霉素酶的分离株），表皮葡萄球菌，不动杆菌属，柠檬酸杆菌属，肠杆菌属，大肠杆菌，克雷伯菌属，M morganii，P菌株的易感菌株而引起的皮肤和皮肤结构感染的治疗寻常型，雷氏假单胞菌，铜绿假单胞菌，沙雷氏菌种，肽球菌种，肽链球菌种，拟杆菌属（包括脆弱类杆菌），梭菌属

美国传染病学会（IDSA）建议：
-切口手术部位感染：每6小时静脉注射500 mg
-皮肤，筋膜和肌肉的结节性感染：每6至8小时静脉输注1 g

评论：
-推荐作为单药治疗肠道或泌尿生殖道手术后的切口手术部位感染
-与其他药物一起，推荐作为治疗由于混合感染而引起的皮肤，筋膜和肌肉坏死性感染的首选方案
-有关更多信息，请参考当前指南。

成年人皮肤和结构感染的常用剂量

如果怀疑/证实是由于易感染细菌引起的感染：每6小时静脉注射500 mg（亚胺培南组分）或每8小时静脉注射1 g（亚胺培南组分）

If infection suspected/proven due to bacterial species with intermediate susceptibility: 1 g (imipenem component) IV every 6 hours

Use: For the treatment of skin and skin structure infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Acinetobacter species, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa, Serratia species, Peptococcus species, Peptostreptococcus species, Bacteroides species (including B fragilis), Fusobacterium species

Infectious Diseases Society of America (IDSA) Recommendations :
-Incisional surgical site infection: 500 mg IV every 6 hours
-Necrotizing infections of the skin, fascia, and muscle: 1 g IV every 6 to 8 hours

评论：
-Recommended as a single-drug regimen for treatment of incisional surgical site infections after intestinal or genitourinary tract surgery
-With other agents, recommended as a preferred regimen for the treatment of necrotizing infections of the skin, fascia, and muscle due to mixed infections
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Nosocomial Pneumonia

IDSA and American Thoracic Society Recommendations: 500 mg IV every 6 hours
Duration of therapy: 7 days

评论：
-With other agents, recommended as an empiric treatment regimen for clinically suspected ventilator-associated pneumonia in units where such coverage is appropriate
-Recommended as initial empiric therapy for hospital-acquired pneumonia (non-ventilator-associated pneumonia)
-Suspected ventilator-associated pneumonia: Dose may need to be reduced in patients less than 70 kg to prevent seizures.
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Peritonitis

International Society for Peritoneal Dialysis (ISPD) Recommendations :
Continuous (all exchanges) :
-Loading dose: 250 mg/L intraperitoneally
-Maintenance dose: 50 mg/L intraperitoneally

Intermittent (1 exchange daily): 500 mg intraperitoneally in alternate exchange

评论：
-Recommended for the treatment of peritoneal dialysis (PD)-related peritonitis
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Bacteremia

Less than 1 week, at least 1500 g: 25 mg/kg (imipenem component) IV every 12 hours
1 to 4 weeks, at least 1500 g: 25 mg/kg (imipenem component) IV every 8 hours
4 weeks to 3 months, at least 1500 g: 25 mg/kg (imipenem component) IV every 6 hours
3 months or older: 15 to 25 mg/kg (imipenem component) IV every 6 hours
Maximum dose: 4 g/day

评论：
-Recommended for non-CNS infections

Uses: For the treatment of :
-Bacterial septicemia due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, P aeruginosa, Serratia species, Bacteroides species (including B fragilis)
-Bone and joint infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Enterobacter species, P aeruginosa
-Endocarditis due to susceptible strains of S aureus (penicillinase-producing isolates)
-Gynecologic infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, S agalactiae (group B streptococci), Enterobacter species, E coli, G vaginalis, Klebsiella species, Proteus species, Bifidobacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis)
-Intraabdominal infections due to susceptible strains of PRIMAXIN is indicated for the treatment of intra-abdominal infections caused by susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, Proteus species, P aeruginosa, Bifidobacterium species, Clostridium species, Eubacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis), Fusobacterium species
-Lower respiratory tract infections due to susceptible strains of S aureus (penicillinase-producing isolates), Acinetobacter species, Enterobacter species, E coli, H influenzae, H parainfluenzae, Klebsiella species, S marcescens
-Skin and skin structure infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Acinetobacter species, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa, Serratia species, Peptococcus species, Peptostreptococcus species, Bacteroides species (including B fragilis), Fusobacterium species
-Urinary tract infections (complicated and uncomplicated) due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa

American Academy of Pediatrics Recommendations :
7 days or younger: 25 mg/kg IV every 12 hours
Greater than 7 days: 25 mg/kg IV every 8 hours
1 month or older: 15 to 25 mg/kg IV 4 times a day
Maximum dose: 4 g/day

评论：
-Caution is recommended when using for treatment of CNS infections due to increased risk of seizures.
-In patients 1 month or older, the higher dose is recommended for P aeruginosa infections.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Endocarditis

Less than 1 week, at least 1500 g: 25 mg/kg (imipenem component) IV every 12 hours
1 to 4 weeks, at least 1500 g: 25 mg/kg (imipenem component) IV every 8 hours
4 weeks to 3 months, at least 1500 g: 25 mg/kg (imipenem component) IV every 6 hours
3 months or older: 15 to 25 mg/kg (imipenem component) IV every 6 hours
Maximum dose: 4 g/day

评论：
-Recommended for non-CNS infections

Uses: For the treatment of :
-Bacterial septicemia due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, P aeruginosa, Serratia species, Bacteroides species (including B fragilis)
-Bone and joint infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Enterobacter species, P aeruginosa
-Endocarditis due to susceptible strains of S aureus (penicillinase-producing isolates)
-Gynecologic infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, S agalactiae (group B streptococci), Enterobacter species, E coli, G vaginalis, Klebsiella species, Proteus species, Bifidobacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis)
-Intraabdominal infections due to susceptible strains of PRIMAXIN is indicated for the treatment of intra-abdominal infections caused by susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, Proteus species, P aeruginosa, Bifidobacterium species, Clostridium species, Eubacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis), Fusobacterium species
-Lower respiratory tract infections due to susceptible strains of S aureus (penicillinase-producing isolates), Acinetobacter species, Enterobacter species, E coli, H influenzae, H parainfluenzae, Klebsiella species, S marcescens
-Skin and skin structure infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Acinetobacter species, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa, Serratia species, Peptococcus species, Peptostreptococcus species, Bacteroides species (including B fragilis), Fusobacterium species
-Urinary tract infections (complicated and uncomplicated) due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa

American Academy of Pediatrics Recommendations :
7 days or younger: 25 mg/kg IV every 12 hours
Greater than 7 days: 25 mg/kg IV every 8 hours
1 month or older: 15 to 25 mg/kg IV 4 times a day
Maximum dose: 4 g/day

评论：
-Caution is recommended when using for treatment of CNS infections due to increased risk of seizures.
-In patients 1 month or older, the higher dose is recommended for P aeruginosa infections.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Intraabdominal Infection

Less than 1 week, at least 1500 g: 25 mg/kg (imipenem component) IV every 12 hours
1 to 4 weeks, at least 1500 g: 25 mg/kg (imipenem component) IV every 8 hours
4 weeks to 3 months, at least 1500 g: 25 mg/kg (imipenem component) IV every 6 hours
3 months or older: 15 to 25 mg/kg (imipenem component) IV every 6 hours
Maximum dose: 4 g/day

评论：
-Recommended for non-CNS infections

Uses: For the treatment of :
-Bacterial septicemia due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, P aeruginosa, Serratia species, Bacteroides species (including B fragilis)
-Bone and joint infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Enterobacter species, P aeruginosa
-Endocarditis due to susceptible strains of S aureus (penicillinase-producing isolates)
-Gynecologic infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, S agalactiae (group B streptococci), Enterobacter species, E coli, G vaginalis, Klebsiella species, Proteus species, Bifidobacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis)
-Intraabdominal infections due to susceptible strains of PRIMAXIN is indicated for the treatment of intra-abdominal infections caused by susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, Proteus species, P aeruginosa, Bifidobacterium species, Clostridium species, Eubacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis), Fusobacterium species
-Lower respiratory tract infections due to susceptible strains of S aureus (penicillinase-producing isolates), Acinetobacter species, Enterobacter species, E coli, H influenzae, H parainfluenzae, Klebsiella species, S marcescens
-Skin and skin structure infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Acinetobacter species, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa, Serratia species, Peptococcus species, Peptostreptococcus species, Bacteroides species (including B fragilis), Fusobacterium species
-Urinary tract infections (complicated and uncomplicated) due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa

American Academy of Pediatrics Recommendations :
7 days or younger: 25 mg/kg IV every 12 hours
Greater than 7 days: 25 mg/kg IV every 8 hours
1 month or older: 15 to 25 mg/kg IV 4 times a day
Maximum dose: 4 g/day

评论：
-Caution is recommended when using for treatment of CNS infections due to increased risk of seizures.
-In patients 1 month or older, the higher dose is recommended for P aeruginosa infections.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Joint Infection

Less than 1 week, at least 1500 g: 25 mg/kg (imipenem component) IV every 12 hours
1 to 4 weeks, at least 1500 g: 25 mg/kg (imipenem component) IV every 8 hours
4 weeks to 3 months, at least 1500 g: 25 mg/kg (imipenem component) IV every 6 hours
3 months or older: 15 to 25 mg/kg (imipenem component) IV every 6 hours
Maximum dose: 4 g/day

评论：
-Recommended for non-CNS infections

Uses: For the treatment of :
-Bacterial septicemia due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, P aeruginosa, Serratia species, Bacteroides species (including B fragilis)
-Bone and joint infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Enterobacter species, P aeruginosa
-Endocarditis due to susceptible strains of S aureus (penicillinase-producing isolates)
-Gynecologic infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, S agalactiae (group B streptococci), Enterobacter species, E coli, G vaginalis, Klebsiella species, Proteus species, Bifidobacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis)
-Intraabdominal infections due to susceptible strains of PRIMAXIN is indicated for the treatment of intra-abdominal infections caused by susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, Proteus species, P aeruginosa, Bifidobacterium species, Clostridium species, Eubacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis), Fusobacterium species
-Lower respiratory tract infections due to susceptible strains of S aureus (penicillinase-producing isolates), Acinetobacter species, Enterobacter species, E coli, H influenzae, H parainfluenzae, Klebsiella species, S marcescens
-Skin and skin structure infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Acinetobacter species, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa, Serratia species, Peptococcus species, Peptostreptococcus species, Bacteroides species (including B fragilis), Fusobacterium species
-Urinary tract infections (complicated and uncomplicated) due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa

American Academy of Pediatrics Recommendations :
7 days or younger: 25 mg/kg IV every 12 hours
Greater than 7 days: 25 mg/kg IV every 8 hours
1 month or older: 15 to 25 mg/kg IV 4 times a day
Maximum dose: 4 g/day

评论：
-Caution is recommended when using for treatment of CNS infections due to increased risk of seizures.
-In patients 1 month or older, the higher dose is recommended for P aeruginosa infections.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Osteomyelitis

Less than 1 week, at least 1500 g: 25 mg/kg (imipenem component) IV every 12 hours
1 to 4 weeks, at least 1500 g: 25 mg/kg (imipenem component) IV every 8 hours
4 weeks to 3 months, at least 1500 g: 25 mg/kg (imipenem component) IV every 6 hours
3 months or older: 15 to 25 mg/kg (imipenem component) IV every 6 hours
Maximum dose: 4 g/day

评论：
-Recommended for non-CNS infections

Uses: For the treatment of :
-Bacterial septicemia due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, P aeruginosa, Serratia species, Bacteroides species (including B fragilis)
-Bone and joint infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Enterobacter species, P aeruginosa
-Endocarditis due to susceptible strains of S aureus (penicillinase-producing isolates)
-Gynecologic infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, S agalactiae (group B streptococci), Enterobacter species, E coli, G vaginalis, Klebsiella species, Proteus species, Bifidobacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis)
-Intraabdominal infections due to susceptible strains of PRIMAXIN is indicated for the treatment of intra-abdominal infections caused by susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, Proteus species, P aeruginosa, Bifidobacterium species, Clostridium species, Eubacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis), Fusobacterium species
-Lower respiratory tract infections due to susceptible strains of S aureus (penicillinase-producing isolates), Acinetobacter species, Enterobacter species, E coli, H influenzae, H parainfluenzae, Klebsiella species, S marcescens
-Skin and skin structure infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Acinetobacter species, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa, Serratia species, Peptococcus species, Peptostreptococcus species, Bacteroides species (including B fragilis), Fusobacterium species
-Urinary tract infections (complicated and uncomplicated) due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa

American Academy of Pediatrics Recommendations :
7 days or younger: 25 mg/kg IV every 12 hours
Greater than 7 days: 25 mg/kg IV every 8 hours
1 month or older: 15 to 25 mg/kg IV 4 times a day
Maximum dose: 4 g/day

评论：
-Caution is recommended when using for treatment of CNS infections due to increased risk of seizures.
-In patients 1 month or older, the higher dose is recommended for P aeruginosa infections.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Pneumonia

Less than 1 week, at least 1500 g: 25 mg/kg (imipenem component) IV every 12 hours
1 to 4 weeks, at least 1500 g: 25 mg/kg (imipenem component) IV every 8 hours
4 weeks to 3 months, at least 1500 g: 25 mg/kg (imipenem component) IV every 6 hours
3 months or older: 15 to 25 mg/kg (imipenem component) IV every 6 hours
Maximum dose: 4 g/day

评论：
-Recommended for non-CNS infections

Uses: For the treatment of :
-Bacterial septicemia due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, P aeruginosa, Serratia species, Bacteroides species (including B fragilis)
-Bone and joint infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Enterobacter species, P aeruginosa
-Endocarditis due to susceptible strains of S aureus (penicillinase-producing isolates)
-Gynecologic infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, S agalactiae (group B streptococci), Enterobacter species, E coli, G vaginalis, Klebsiella species, Proteus species, Bifidobacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis)
-Intraabdominal infections due to susceptible strains of PRIMAXIN is indicated for the treatment of intra-abdominal infections caused by susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, Proteus species, P aeruginosa, Bifidobacterium species, Clostridium species, Eubacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis), Fusobacterium species
-Lower respiratory tract infections due to susceptible strains of S aureus (penicillinase-producing isolates), Acinetobacter species, Enterobacter species, E coli, H influenzae, H parainfluenzae, Klebsiella species, S marcescens
-Skin and skin structure infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Acinetobacter species, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa, Serratia species, Peptococcus species, Peptostreptococcus species, Bacteroides species (including B fragilis), Fusobacterium species
-Urinary tract infections (complicated and uncomplicated) due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa

American Academy of Pediatrics Recommendations :
7 days or younger: 25 mg/kg IV every 12 hours
Greater than 7 days: 25 mg/kg IV every 8 hours
1 month or older: 15 to 25 mg/kg IV 4 times a day
Maximum dose: 4 g/day

评论：
-Caution is recommended when using for treatment of CNS infections due to increased risk of seizures.
-In patients 1 month or older, the higher dose is recommended for P aeruginosa infections.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Pyelonephritis

Less than 1 week, at least 1500 g: 25 mg/kg (imipenem component) IV every 12 hours
1 to 4 weeks, at least 1500 g: 25 mg/kg (imipenem component) IV every 8 hours
4 weeks to 3 months, at least 1500 g: 25 mg/kg (imipenem component) IV every 6 hours
3 months or older: 15 to 25 mg/kg (imipenem component) IV every 6 hours
Maximum dose: 4 g/day

评论：
-Recommended for non-CNS infections

Uses: For the treatment of :
-Bacterial septicemia due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, P aeruginosa, Serratia species, Bacteroides species (including B fragilis)
-Bone and joint infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Enterobacter species, P aeruginosa
-Endocarditis due to susceptible strains of S aureus (penicillinase-producing isolates)
-Gynecologic infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, S agalactiae (group B streptococci), Enterobacter species, E coli, G vaginalis, Klebsiella species, Proteus species, Bifidobacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis)
-Intraabdominal infections due to susceptible strains of PRIMAXIN is indicated for the treatment of intra-abdominal infections caused by susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, Proteus species, P aeruginosa, Bifidobacterium species, Clostridium species, Eubacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis), Fusobacterium species
-Lower respiratory tract infections due to susceptible strains of S aureus (penicillinase-producing isolates), Acinetobacter species, Enterobacter species, E coli, H influenzae, H parainfluenzae, Klebsiella species, S marcescens
-Skin and skin structure infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Acinetobacter species, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa, Serratia species, Peptococcus species, Peptostreptococcus species, Bacteroides species (including B fragilis), Fusobacterium species
-Urinary tract infections (complicated and uncomplicated) due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa

American Academy of Pediatrics Recommendations :
7 days or younger: 25 mg/kg IV every 12 hours
Greater than 7 days: 25 mg/kg IV every 8 hours
1 month or older: 15 to 25 mg/kg IV 4 times a day
Maximum dose: 4 g/day

评论：
-Caution is recommended when using for treatment of CNS infections due to increased risk of seizures.
-In patients 1 month or older, the higher dose is recommended for P aeruginosa infections.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Septicemia

Less than 1 week, at least 1500 g: 25 mg/kg (imipenem component) IV every 12 hours
1 to 4 weeks, at least 1500 g: 25 mg/kg (imipenem component) IV every 8 hours
4 weeks to 3 months, at least 1500 g: 25 mg/kg (imipenem component) IV every 6 hours
3 months or older: 15 to 25 mg/kg (imipenem component) IV every 6 hours
Maximum dose: 4 g/day

评论：
-Recommended for non-CNS infections

Uses: For the treatment of :
-Bacterial septicemia due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, P aeruginosa, Serratia species, Bacteroides species (including B fragilis)
-Bone and joint infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Enterobacter species, P aeruginosa
-Endocarditis due to susceptible strains of S aureus (penicillinase-producing isolates)
-Gynecologic infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, S agalactiae (group B streptococci), Enterobacter species, E coli, G vaginalis, Klebsiella species, Proteus species, Bifidobacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis)
-Intraabdominal infections due to susceptible strains of PRIMAXIN is indicated for the treatment of intra-abdominal infections caused by susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, Proteus species, P aeruginosa, Bifidobacterium species, Clostridium species, Eubacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis), Fusobacterium species
-Lower respiratory tract infections due to susceptible strains of S aureus (penicillinase-producing isolates), Acinetobacter species, Enterobacter species, E coli, H influenzae, H parainfluenzae, Klebsiella species, S marcescens
-Skin and skin structure infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Acinetobacter species, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa, Serratia species, Peptococcus species, Peptostreptococcus species, Bacteroides species (including B fragilis), Fusobacterium species
-Urinary tract infections (complicated and uncomplicated) due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa

American Academy of Pediatrics Recommendations :
7 days or younger: 25 mg/kg IV every 12 hours
Greater than 7 days: 25 mg/kg IV every 8 hours
1 month or older: 15 to 25 mg/kg IV 4 times a day
Maximum dose: 4 g/day

评论：
-Caution is recommended when using for treatment of CNS infections due to increased risk of seizures.
-In patients 1 month or older, the higher dose is recommended for P aeruginosa infections.
-Current guidelines should be consulted for additional information.

细菌感染的常用儿科剂量

Less than 1 week, at least 1500 g: 25 mg/kg (imipenem component) IV every 12 hours
1 to 4 weeks, at least 1500 g: 25 mg/kg (imipenem component) IV every 8 hours
4 weeks to 3 months, at least 1500 g: 25 mg/kg (imipenem component) IV every 6 hours
3 months or older: 15 to 25 mg/kg (imipenem component) IV every 6 hours
Maximum dose: 4 g/day

评论：
-Recommended for non-CNS infections

Uses: For the treatment of :
-Bacterial septicemia due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, P aeruginosa, Serratia species, Bacteroides species (including B fragilis)
-Bone and joint infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Enterobacter species, P aeruginosa
-Endocarditis due to susceptible strains of S aureus (penicillinase-producing isolates)
-Gynecologic infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, S agalactiae (group B streptococci), Enterobacter species, E coli, G vaginalis, Klebsiella species, Proteus species, Bifidobacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis)
-Intraabdominal infections due to susceptible strains of PRIMAXIN is indicated for the treatment of intra-abdominal infections caused by susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, Proteus species, P aeruginosa, Bifidobacterium species, Clostridium species, Eubacterium species, Peptococcus species, Peptostreptococcus species, Propionibacterium species, Bacteroides species (including B fragilis), Fusobacterium species
-Lower respiratory tract infections due to susceptible strains of S aureus (penicillinase-producing isolates), Acinetobacter species, Enterobacter species, E coli, H influenzae, H parainfluenzae, Klebsiella species, S marcescens
-Skin and skin structure infections due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), S epidermidis, Acinetobacter species, Citrobacter species, Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa, Serratia species, Peptococcus species, Peptostreptococcus species, Bacteroides species (including B fragilis), Fusobacterium species
-Urinary tract infections (complicated and uncomplicated) due to susceptible strains of E faecalis, S aureus (penicillinase-producing isolates), Enterobacter species, E coli, Klebsiella species, M morganii, P vulgaris, P rettgeri, P aeruginosa

American Academy of Pediatrics Recommendations :
7 days or younger: 25 mg/kg IV every 12 hours
Greater than 7 days: 25 mg/kg IV every 8 hours
1 month or older: 15 to 25 mg/kg IV 4 times a day
Maximum dose: 4 g/day

评论：
-Caution is recommended when using for treatment of CNS infections due to increased risk of seizures.
-In patients 1 month or older, the higher dose is recommended for P aeruginosa infections.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Urinary Tract Infection

Less than 1 week, at least 1500 g: 25 mg/kg (imipenem component) IV every 12 hours
1 to 4 weeks, at least 1500 g: 25 mg/kg (imipenem component) IV every 8 hours
4 weeks to 3 months, at least 1500 g: 25 mg/kg (imipenem component) IV every 6 hours
3 months or older: 15 to 25 mg/kg (imipenem component) IV every 6 hours
Maximum dose: 4 g/day